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fortune gems jili bet CLEVELAND (AP) — Alyssa Nakken, the first woman to coach in a Major League Baseball game, is leaving the San Francisco Giants to join the Cleveland Guardians. Nakken made history in 2022 when she took over as first-base coach following an ejection. A former college softball star at Sacramento State, Nakken joined the Giants in 2014 and was promoted to a spot on manager Gabe Kapler's staff in 2020, becoming the majors' first full-time female coach. Nakken has been hired as an assistant director within player development for the Guardians, who won the AL Central last season under first-year manager Stephen Vogt — the AL Manager of the Year. With Cleveland, the 34-year-old Nakken will work with former Giants coaches Craig Albernaz and Kai Correa. Her exact duties are still being determined. "We thank Alyssa Nakken for her incredible contributions to the San Francisco Giants and for trailblazing a path for women in sports,” the Giants said in a statement on Friday. "Her leadership, dedication, and passion for the game have inspired countless individuals, and her impact has been truly transformative for the Giants organization and the baseball community. “As she embarks on this exciting new chapter in her career, we have no doubt that she’ll continue to inspire and achieve great things. We wish her and her family nothing but the best.” Nakken is the second on-field female coach hired by the Guardians. In 2023, the club brought in Amanda Kamekona as their hitting development coach for their year-round training academy in Goodyear, Arizona. Last season, she was an assistant hitting coach at Double-A Akron. Kamekona was twice a third-team All-American at UCLA after transferring from Cal State Fullerton. AP MLB: https://apnews.com/hub/mlbAs Arsenal struggles to find its footing in the Premier League and compete against top teams, the missed opportunities in the transfer window have come under intense scrutiny, with many questioning Arteta's decision-making and the club's transfer strategy. The lack of key reinforcements in crucial areas of the squad has hampered Arsenal's progress and raised doubts about their ability to challenge for major honors in the near future.

White Jingting, also known as Bai Jingting, has been making waves in the Chinese entertainment industry with his exceptional acting skills and undeniable charm. From his breakout role in the hit drama series "Love O2O" to his more recent performances in critically acclaimed films, White Jingting has captured the hearts of fans across the nation. Now, he is taking his career to new heights as he ventures into the world of outdoor fashion, becoming the brand ambassador for Salomon, a leading outdoor sports brand known for its high-quality apparel and footwear.FDA approves cancer drug developed by B.C.'s Zymeworks Cancer drug developed by Zymeworks in partnership with Jazz Pharmaceuticals Nelson Bennett Nov 21, 2024 3:45 PM Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message B.C. biotech Zymeworks developed a drug discovery engine that has produced multiple candidates for treating cancers. Tyler Orton Listen to this article 00:02:29 The U.S. Food Drug Administration (FDA) has granted accelerated approval of a new drug for treating bilary tract cancer that was developed by Vancouver’ s Zymeworks Inc. (Nasdaq: ZYME) under a licensing and commercialization agreement with Jazz Pharmaceuticals. The new drug, Ziihera, could net Zymeworks more than $1 billion just in milestone payments, and millions more in royalties, upon full commercialization. Gaining the FDA’s accelerated approval triggers a $25 million milestone payment to Zymeworks from Jazz Pharmaceuticals – the first of more to come, should other milestones be reached. Under its licensing agreement, Zymeworks is eligible for up to $500 million in regulatory milestones, $862.5 million in commercial milestone payments, and royalties of 10 to 20 per cent on sales. “This approval represents the first FDA-approved therapy in Zymeworks’ pipeline, and validates the company’s novel Azymetric bispecific platform technology and internal research and development capabilities for novel multifunctional medicines,” Zymeworks says in a news release. “The FDA’s accelerated approval of Ziihera marks the culmination of more than a decade of research and development at Zymeworks, highlighting our deep scientific expertise in multifunctional biotherapeutics and unwavering commitment to innovation in drug development,” said Paul Moore, Zymeworks’ chief science officer. Ziihera is one of several variations of the bispecific antibody Zanidatamab that Zymeworks developed for treating various types of cancer, and one of three in the advanced “pivotal” trial phase. Several others are at phase 2 in clinical trials. In 2022, Zymeworks entered a licence and collaboration agreement with Jazz Pharmaceuticals Ireland Ltd -- a subsidiary of Jazz Pharmaceuticals plc -- for the exclusive development and commercialization rights to Zanidatamab in the U.S., Europe, Japan and other countries. A study published last year in The Lancet concluded that Zanidatamab “demonstrated meaningful clinical benefit with a manageable safety profile in patients with treatment-refractory, HER2-positive biliary tract cancer.” [email protected] twitter.com/nbennett_biv See a typo/mistake? Have a story/tip? This has been shared 0 times 0 Shares Share by Email Share on Facebook Share on X Share on LinkedIn Print Share via Text Message Get your daily Victoria news briefing Email Sign Up More Technology CRTC opens consultation on whether Big 3 telecoms can sell wholesale fibre internet Nov 21, 2024 2:05 PM How B.C.'s cleantech startups are cracking resource sector challenges Nov 20, 2024 4:00 PM Opinion: If TikTok poses a grave threat to national security, why are Canadians told they can keep using it? Nov 18, 2024 8:00 PM

TACOMA, Wash., Dec. 26, 2024 (GLOBE NEWSWIRE) -- GROUPIRA®, INC. (GROUPIRA®), a leader in financial technology innovation, proudly announces the launch of GROUPIRA® 5.0, a groundbreaking platform designed to revolutionize individual retirement account (IRA) rollovers for its channel partners. By leveraging advanced technologies such as Microsoft Azure, FIS Relius, LexisNexis, Plaid, DocuSign, and Veratad, GROUPIRA® 5.0 enhances efficiency, accuracy, and automation in the rollover process. In addition to this milestone, GROUPIRA® is developing a customized online account origination solution tailored for external retirement plan advisers. This new solution will streamline the onboarding process, enabling advisers to seamlessly integrate their unique point-of-sale documentation and account management forms for Member Clients. Yannis Koumantaros, Co-Founder and President of GROUPIRA®, highlighted the evolution of the platform: “From streamlining rollover claims with GROUPIRA® 3.0 to simplifying automatic enrollments with GROUPIRA® 4.0, each iteration of our platform has been about innovation and efficiency. With GROUPIRA® 5.0, we’re giving valuable time back to our channel partners by automating data transfers using advanced tools with Microsoft Azure leveraging APIs and Secure File Transfer Protocols (SFTPs). These technologies work together to move data securely and seamlessly.” Petros Koumantaros, Co-Founder and Chairperson of GROUPIRA®, expressed pride in the team's accomplishments: “Our dedicated engineering team continues to deliver on schedule, achieving major development milestones. Looking ahead, GROUPIRA® 6.0 will further enhance automation by merging PDFs for channel partners, allowing us to manage millions of accounts while expanding access to retirement plan solutions nationwide.” About GROUPIRA®, INC. GROUPIRA®, Inc. is a pioneering financial technology company committed to bringing the benefits of 401(k) plans to IRA investors. To discover more about GROUPIRA® and its innovative solutions, visit www.groupira.com . Media Contact: Yannis Koumantaros, yannis@groupira.com , 253-592-6687But it's not just the romance that makes 'Feast Chronicles' a must-watch. The series is also filled with thrilling plot twists, unexpected turns, and moments of heart-wrenching emotion that will leave viewers reaching for the tissues. Each episode is a feast for the senses, serving up a delicious mix of passion, intrigue, and suspense that will keep viewers coming back for more.

Authorities have called off the search for a 51-year-old man who went overboard Thursday on a Norwegian Cruise Line vessel. The man, who was traveling with his family, went over the side around 3 p.m. while the ship was sailing from Ocho Rios, Jamaica to Nassau, Bahamas, the cruise line said in a statement to USA TODAY. A rescue operation took place but was ultimately called off so the ship could continue its voyage. "The guest was traveling with a large group and his family on board is being attended to and supported during this very challenging situation," a spokesperson for Norwegian Cruise Line said in a statement to USA TODAY. "Our thoughts and prayers are with his loved ones during this difficult time.” Man goes overboard on Norwegian Epic The vessel that the man and his family were traveling aboard was a Norwegian Epic cruise ship, a voyage known for its onboard performances, activities and pampering experiences . The Norwegian Epic is in the midst of a seven-night Western Caribbean voyage after departing Saturday from Canaveral, Florida, according to Cruise Hive , a cruise industry blog. After cruise officials learned that the man had gone over the side, authorities were notified and a search began under the guidance of the Bahamas Rescue Coordination Center, the cruise line told USA TODAY. Many passengers assisted in the search and shared updates on social media as onboard announcements indicated that the individual was wearing a blue shirt. Holland America Line’s Zuiderdam, which was nearby, also joined in the search, Cruise Hive reported. "After an extensive search that was unfortunately unsuccessful, the ship was released by the authorities," the Norwegian Cruise Line spokesperson said in a statement. It was not immediately clear what caused the man to go overboard. The man has not been identified. Eric Lagatta covers breaking and trending news for USA TODAY. Reach him at elagatta@gannett.comThe United Arab Emirates is a rapidly developing nation with strong economic and political ambitions. Pursuing strategic goals of diversification, the UAE is actively expanding its international connections and aiming to strengthen its position on the global stage. This initiative is taking place amid significant changes in global politics, as the longstanding world order, which has shaped the rules of engagement for many years, increasingly shows its inability to account for the interests of non-Western countries like the UAE. Faced with the challenges of the old system, the UAE is actively seeking ways to reinforce its independence. Joining BRICS on January 1, 2024 was a crucial step in this direction, providing not only a reduction in reliance on Western countries but also the opportunity to promote its own interests on a global level. The BRICS bloc, which includes Brazil, Russia, China, India, and South Africa, serves as an alternative platform where the interests of developing and rapidly growing economies are considered equally. For Abu Dhabi, membership of BRICS represents a significant strategic reorientation. The UAE is aiming to build its international relations with greater flexibility and to diversify its economic partnerships, which will be a key step in reinforcing its sovereignty and resilience amid global uncertainty. Membership of BRICS opens significant opportunities for the UAE to strengthen its position on the global stage. With one of the most rapidly developing economies in the region, the UAE aims to diversify its international economic ties and reduce dependence on traditional partners. Joining BRICS grants the UAE better access to several large and promising markets, which will allow it to expand trade and reinforce investment ties. The combined GDP of BRICS countries constitutes a substantial part of the global economy, and participation in this alliance creates new prospects for the UAE to grow its exports and imports. In 2023, for example, China’s GDP reached $17.96 trillion, India’s $3.4 trillion, and Russia’s $1.7 trillion. These figures demonstrate the immense economic potential now accessible to the UAE. Membership of BRICS also opens pathways for attracting significant investment, which is particularly important for the development of the UAE’s infrastructure, technology, and industry. In 2023, BRICS countries saw a substantial increase in foreign direct investment, highlighting high investor interest and presenting new opportunities for the UAE. Another key advantage of BRICS membership is access to the organization’s financial resources. The BRICS-established New Development Bank provides funding for major infrastructure projects and fosters economic development among member states. The UAE can leverage these resources to undertake large-scale projects that will contribute to its economic growth and modernization. Additionally, BRICS membership aligns with the UAE’s political ambitions by allowing it to actively shape the global agenda and ensure its influence in international processes. As the world transitions toward a multipolar system in which developing countries play a more prominent role, BRICS participation offers the UAE a platform from which to promote its own interests, such as energy security, sustainable development, and trade issues. Moreover, BRICS membership reduces dependence on traditional Western partners, enabling the UAE to conduct a more flexible and balanced foreign policy, establishing relationships with various countries and blocs on equal terms. Despite the clear advantages, BRICS membership presents certain challenges. The UAE may face difficulties in adapting to the economic and political approaches of BRICS countries, as the alliance comprises nations with diverse economic structures and development levels. However, the UAE’s flexibility and willingness to compromise, core to its foreign policy strategy, will help it overcome these challenges. Another potential risk is the reaction from traditional Western partners, who may view this step as a threat to their influence in the region. Nonetheless, for the UAE, participation in BRICS is fundamentally a path to strengthening its independence and autonomy, while remaining committed to the principles of multilateral diplomacy and cooperation. Overall, despite the challenges, the benefits of BRICS membership for the UAE far outweigh any possible risks. Participation in the bloc enables the UAE to develop trade and investment relations, advance its interests globally, and establish stable mechanisms for economic growth. Amid global instability and change, the UAE can, through BRICS, reinforce its position in international politics and the economy, contributing to a more balanced and multipolar global order. The entry of the UAE, with one of the most advanced economies in the Arab world, opens new horizons for all BRICS members by granting access to a strategically significant region and a rapidly growing economy. With a GDP of $421 billion in 2023, the UAE already holds a leading position in the Arab world. The country’s economy is characterized by high growth rates, diversification, and a high per capita income of around $47,000. These indicators make the UAE an attractive partner for BRICS, expanding the bloc’s economic potential. The UAE's membership of BRICS strengthens its overall economic weight, providing access to financial resources and substantial investment opportunities in the Gulf region, which is considered one of the most promising in the world by capital volume. In addition, the UAE occupies a strategically important geographical position at the intersection of trade routes between Asia, Europe, and Africa. This offers BRICS the potential to strengthen its logistics and trade links with various regions, increasing trade volumes and investment flows. Currently, approximately 40% of global maritime shipping passes through the Strait of Hormuz, controlled by Gulf countries, including the UAE. The UAE’s position on this trade route makes it an ideal partner for supporting the development of infrastructure and logistics projects, especially within the framework of the “One Belt, One Road” initiative, backed by some BRICS countries. Thus, the UAE’s participation may accelerate the implementation of strategic projects that enhance BRICS’ role in international trade. Beyond economic factors, the UAE’s participation in BRICS brings substantial political advantages. The UAE wields significant influence in the Arab and Muslim world, making it a crucial partner for BRICS in expanding the bloc’s political influence in the region. As BRICS aims to create a more multipolar world and reduce the influence of Western countries in international processes, UAE membership provides additional diplomatic leverage to the bloc. The UAE, like other BRICS countries, supports the idea of an international system where the interests of developing nations are considered equally alongside those of Western states. In this way, the UAE’s involvement helps strengthen BRICS as a global coalition of nations striving for a fairer distribution of power worldwide. However, despite all these benefits, UAE membership of BRICS may present certain challenges. One of these relates to differences in economic and political priorities. The economic interests of BRICS countries are not uniform, and the integration of a new country requires effort to reach consensus on key issues such as energy and trade. Differences in approaches to foreign policy and the potential impact on relations with Western countries may also be obstacles. It is important to note, however, that the UAE’s multivector foreign policy approach allows it to flexibly balance its interests, which mitigates these potential risks. Overall, the benefits of UAE membership in BRICS far outweigh the potential difficulties. The bloc’s strength and resilience grow with this new partner, which brings a developed economy and strategically important location. The UAE’s involvement boosts the investment and trade potential of BRICS, providing access to the financial resources and opportunities of the Gulf region. As previously noted, BRICS and the United Arab Emirates share a common goal of creating a more fair and balanced global order in which the economic and political interests of all countries are valued equally alongside those of traditional Western powers. At the heart of this vision lies the idea of moving away from an outdated model of global governance dominated by a few developed nations and towards a multipolar system that places greater emphasis on state sovereignty and equality. The foreign policy stance of BRICS countries is aimed at establishing conditions where not only the major Western economies but also developing nations can participate equally in addressing global issues. This approach is reflected in initiatives such as the New Development Bank and BRICS cooperation mechanisms, which provide developing countries with access to financial resources and alternatives to Western financial institutions. The UAE, despite its historically close ties with the West, also supports a multi-directional approach, seeking to reinforce its economic and political independence. Joining BRICS allows the UAE to complement its existing partnerships within an emerging multipolar world and to avoid dependence on any one side. The alignment between BRICS and the UAE lies in their shared understanding of the need for a more equitable global framework, where the interests of economies in development are considered equally with those of traditional global centers. Combining efforts in this direction creates potential for establishing more favorable conditions that support sustainable development, protect economic interests, and maintain political autonomy for each bloc member. BRICS and the UAE see this partnership as an opportunity to strengthen their positions in global politics and economics, safeguarding their interests and advancing the principles of equal participation. The similarity in their approaches is also evident in the desire to reduce dependency on the US dollar and Western financial systems, thereby granting more freedom to developing markets. Within BRICS, initiatives are being discussed to create mechanisms for transactions in national currencies and to reduce the role of the dollar, which would enable countries to avoid currency risks and dependence on US foreign policy decisions. With its strong economy and status as one of the largest exporters of oil and gas, the UAE can support this initiative, contributing to greater economic independence from Western financial centers. UAE support strengthens BRICS’ initiatives to build a more independent and fair financial system, which will create more favorable and stable conditions for economic growth and cooperation. In summary, it can be assumed that UAE membership in BRICS is beneficial for both sides. BRICS gains access to the resources and economic opportunities of the Gulf region, while the UAE enhances its international standing as part of a bloc focused on establishing a fair global order. Amid rising global instability and an increasing need for resilient international connections, the combined efforts of BRICS countries and the UAE could form a foundation for a more balanced and stable international system, ensuring a future where the interests of all nations are respected and valued.

The resumption of 737 MAX production comes at a critical time for Boeing, as the company continues to face challenges related to the aircraft model's safety and certification. The 737 MAX was grounded worldwide in March 2019 following two fatal crashes that claimed the lives of 346 people. Since then, Boeing has been working closely with regulatory authorities to address the issues that led to the crashes and to ensure the aircraft's safe return to service.As the investigation into the dental medical institution in Dalian progresses, it is hoped that the truth will be brought to light, and appropriate measures will be taken to address any wrongdoing. The authorities must send a clear message that false advertising and deceptive practices will not be tolerated in the healthcare industry. By upholding the principles of honesty and transparency, we can protect the interests and well-being of patients and uphold the integrity of the healthcare profession.

Sale thrash Bristol to move into Gallagher Premiership play-offs