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— Oct. 1, 1924: James Earl Carter Jr. is born in Plains, Georgia, son of James Sr. and Lillian Gordy Carter. — June 1946: Carter graduates from the U.S. Naval Academy. — July 1946: Carter marries Rosalynn Smith, in Plains. They have four children, John William (“Jack”), born 1947; James Earl 3rd (“Chip”), 1950; Donnel Jeffrey (Jeff), 1952; and Amy Lynn, 1967. — 1946-1953: Carter serves in a Navy nuclear submarine program, attaining rank of lieutenant commander. — Summer 1953: Carter resigns from the Navy, returns to Plains after father’s death. — 1953-1971: Carter helps run the family peanut farm and warehouse business. — 1963-1966: Carter serves in the Georgia state Senate. — 1966: Carter tries unsuccessfully for the Democratic gubernatorial nomination. — November 1970: Carter is elected governor of Georgia. Serves 1971-75. — Dec. 12, 1974: Carter announces a presidential bid. Atlanta newspaper answers with headline: “Jimmy Who?” — January 1976: Carter leads the Democratic field in Iowa, a huge campaign boost that also helps to establish Iowa’s first-in-the-nation caucus. — July 1976: Carter accepts the Democratic nomination and announces Sen. Walter Mondale of Minnesota as running mate. — November 1976: Carter defeats President Gerald R. Ford, winning 51% of the vote and 297 electoral votes to Ford’s 240. — January 1977: Carter is sworn in as the 39th president of the United States. On his first full day in office, he pardons most Vietnam-era draft evaders. —September 1977: U.S. and Panama sign treaties to return the Panama Canal back to Panama in 1999. Senate narrowly ratifies them in 1978. — September 1978: Egyptian President Anwar Sadat, Israeli Prime Minister Menachem Begin and Carter sign Camp David accords, which lead to a peace deal between Egypt and Israel the following year. — June 15-18, 1979: Carter attends a summit with Soviet President Leonid Brezhnev in Vienna that leads to the signing of the SALT II treaty. — November 1979: Iranian militants storm the U.S. Embassy in Tehran, taking 52 hostages. All survive and are freed minutes after Carter leaves office in January 1981. — April 1980: The Mariel boatlift begins, sending tens of thousands of Cubans to the U.S. Many are criminals and psychiatric patients set free by Cuban leader Fidel Castro, creating a major foreign policy crisis. — April 1980: An attempt by the U.S. to free hostages fails when a helicopter crashes into a transport plane in Iran, killing eight servicemen. — Nov. 4, 1980: Carter is denied a second term by Ronald Reagan, who wins 51.6% of the popular vote to 41.7% for Carter and 6.7% to independent John Anderson. — 1982: Jimmy and Rosalynn Carter co-found The Carter Center in Atlanta, whose mission is to resolve conflicts, protect human rights and prevent disease around the world. — September 1984: The Carters spend a week building Habitat for Humanity houses, launching what becomes the annual Carter Work Project. — October 1986: A dedication is held for The Carter Presidential Center in Atlanta. The center includes the Carter Presidential Library and Museum and Carter Center offices. — 1989: Carter leads the Carter Center’s first election monitoring mission, declaring Panamanian Gen. Manuel Noriega’s election fraudulent. — May 1992: Carter meets with Mikhail and Raisa Gorbachev at the Carter Center to discuss forming the Gorbachev Foundation. — June 1994: Carter plays a key role in North Korea nuclear disarmament talks. — September 1994: Carter leads a delegation to Haiti, arranging terms to avoid a U.S. invasion and return President Jean-Bertrand Aristide to power. — December 1994: Carter negotiates tentative cease-fire in Bosnia. — March 1995: Carter mediates cease-fire in Sudan’s war with southern rebels. — September 1995: Carter travels to Africa to advance the peace process in more troubled areas. — December 1998: Carter receives U.N. Human Rights Prize on 50th anniversary of the Universal Declaration of Human Rights. — August 1999: President Bill Clinton awards Jimmy and Rosalynn Carter the Presidential Medal of Freedom. — September 2001: Carter joins former Presidents Ford, Bush and Clinton at a prayer service at the National Cathedral in Washington after Sept. 11 attacks. — April 2002: Carter’s book “An Hour Before Daylight: Memories of a Rural Boyhood” chosen as finalist for Pulitzer Prize in biography. — May 2002: Carter visits Cuba and addresses the communist nation on television. He is the highest-ranking American to visit in decades. — Dec. 10, 2002: Carter is awarded the Nobel Peace Prize for his “untiring effort to find peaceful solutions to international conflicts, to advance democracy and human rights, and to promote economic and social development.” — July 2007: Carter joins The Elders, a group of international leaders brought together by Nelson Mandela to focus on global issues. — Spring 2008: Carter remains officially neutral as Sens. Barack Obama and Hillary Rodham Clinton battle each other for the Democratic presidential nomination. — April 2008: Carter stirs controversy by meeting with the Islamic militant group Hamas. — August 2010: Carter travels to North Korea as the Carter Center negotiates the release of an imprisoned American teacher. — August 2013: Carter joins President Barack Obama and former President Bill Clinton at the 50th anniversary of the Rev. Martin Luther King Jr.’s “I Have A Dream” speech and the March on Washington. — Oct. 1, 2014: Carter celebrates his 90th birthday. — December 2014: Carter is nominated for a Grammy in the best spoken word album category, for his book “A Call To Action.” — May 2015: Carter returns early from an election observation visit in Guyana — the Carter Center’s 100th — after feeling unwell. — August 2015: Carter has a small cancerous mass removed from his liver. He plans to receive treatment at Emory Healthcare in Atlanta. — August 2015: Carter announces that his grandson Jason Carter will chair the Carter Center governing board. — March 6, 2016: Carter says an experimental drug has eliminated any sign of his cancer, and that he needs no further treatment. — May 25, 2016: Carter steps back from a “front-line” role with The Elders to become an emeritus member. — July 2016: Carter is treated for dehydration during a Habitat for Humanity build in Canada. — Spring 2018: Carter publishes “Faith: A Journey for All,” the last of 32 books. — March 22, 2019: Carter becomes the longest-lived U.S. president, surpassing President George H.W. Bush, who died in 2018. — September 18, 2019: Jimmy and Rosalynn Carter deliver their final in-person annual report at the Carter Center. — October 2019: At 95, still recovering from a fall, Carter joins the Work Project with Habitat for Humanity in Nashville, Tennessee. It’s the last time he works personally on the annual project. — Fall 2019-early 2020: Democratic presidential hopefuls visit, publicly embracing Carter as a party elder, a first for his post-presidency. — November 2020:The Carter Center monitors an audit of presidential election results in the state of Georgia, marking a new era of democracy advocacy within the U.S. — Jan. 20, 2021: The Carters miss President Joe Biden’s swearing-in, the first presidential inauguration they don’t attend since Carter’s own ceremony in 1977. The Bidens later visit the Carters in Plains on April 29. — Feb. 19, 2023: Carter enters home hospice care after a series of short hospital stays. — July 7, 2023: The Carters celebrate their 77th and final wedding anniversary. — Nov. 19, 2023: Rosalynn Carter dies at home, two days after the family announced that she had joined the former president in receiving hospice care. — Oct. 1, 2024 — Carter becomes the first former U.S. president to reach 100 years of age , celebrating at home with extended family and close friends. — Oct. 16, 2024 — Carter casts a Georgia mail ballot for Democratic presidential nominee Kamala Harris, having told his family he wanted to live long enough to vote for her. It marks his 21st presidential election as a voter. — Dec. 29, 2024: Carter dies at home.Shares of Arrowhead Pharmaceuticals Inc. ($ARWR) and Sarepta Therapeutics Inc. ($SRPT) climbed on Wednesday despite Wall Street trimming price targets after the companies announced a $1 billion licensing agreement. Under the deal, Sarepta gains exclusive global rights to multiple programs targeting rare genetic diseases affecting muscles, the central nervous system, and lungs. In return, Arrowhead will receive $825 million upfront, comprising $500 million in cash and $325 million in equity at a 35% premium. An additional $250 million will be paid in installments over the next five years. Arrowhead is also eligible for up to $10 billion in potential milestones and low double-digit royalties. Needham lowered Sarepta’s price target to $202 from $205, maintaining a ‘Buy’ rating. But the brokerage praised the deal for its platform diversification and alignment with Sarepta’s rare genetic medicine expertise. Piper Sandler cut Arrowhead’s price target to $45 from $62, keeping an ‘Overweight’ rating. The brokerage sees the collaboration as transformative, with Sarepta acquiring clinical and preclinical TRiM programs. Piper also reduced Sarepta’s price target to $182 from $200, highlighting the partnership’s pipeline expansion and near-term financial impact. Citi reduced Arrowhead’s price target to $26 from $27, maintaining a ‘Neutral’ stance. The analyst noted Arrowhead’s extended cash runway through 2028, aided by this deal and a strategic financing arrangement with Sixth Street. Arrowhead ranked among the top 10 trending symbols on Stocktwits by Wednesday afternoon, with a good dose of optimistic retail chatter driving activity for both stocks. However, a bearish overhang remains for Arrowhead after it missed fiscal fourth-quarter expectations on Tuesday, reporting a loss of $1.36 per share (vs. a $0.97 loss consensus) and $35 million in revenue (vs. $55.07 million expected). Arrowhead’s CEO emphasized the company’s readiness to commercialize medicines, spotlighting the recent submission of its first New Drug Application (NDA) to the FDA for plozasiran, which could launch in 2025 pending approval. Year-to-date, Arrowhead shares have declined over 14%, while Sarepta has surged more than 40%. For updates and corrections email newsroom[at]stocktwits[dot]com.

If you want to turn climate policy into a bitter culture war, there are few more effective weapons than a Big Mac. On one side, environmentalists will point out that the cattle we raise cause about as much greenhouse pollution as all the world’s cars, trucks, ships and planes. On the other, irritated meat-lovers will call you a killjoy, and warn you don’t win friends with salad. There’s one place where the opposing groups agree, however: As incomes rise and allow people to buy more of it, beef-eating is such an irresistible habit that only implausibly radical behavioral changes can stop things spiraling still further out of control. They’re both wrong about that, though. As we’ve argued in the past, the world is rapidly closing in on peak beef. It’s possible that the carbon hoofprint of the global cattle herd is already in decline. That’s certainly the assessment suggested by the U.S. Department of Agriculture’s data. More than 90 percent of the world’s additional demand for meat over the past 15 years has been met by less carbon-intensive products. Consumption of chicken increased by 35 percent, or 27 million metric tons, between 2010 and the agency’s forecast for 2025 demand, while pork is up by 12 million tons, or 12 percent. Beef, whose heavy methane load is due to burped gases from ruminant stomachs that poultry and pigs lack, increased by a mere 3.6 million tons, or 6.3 percent. Such numbers are particularly striking when you consider that the world’s population increased by about 15 percent between 2010 and 2023, and the global economy is about 43 percent larger, adjusted for inflation. Our appetite for burgers, steak and mince hasn’t increased at anything like the same rate. This suggests the constraint on beef production is not our guts and wallets, but more fundamental constraints of resource availability. The same factor that worries environmentalists about beef — its voracious ability to consume land, water, feed crops and the planet’s carbon budget — puts limits on the ability for supplies to grow. Diners might not need to self-consciously reject red meat at all, when the availability of cheaper fish, chicken, pork and vegetarian options is enough to cause an imperceptible shift away from it. By the USDA’s numbers, those factors may already by causing a decline in the worldwide herd. From a peak of more than a billion head of cattle in the mid-2000s, stocks at the start of next year will fall to 923 million head, a record low in their data. That may seem inconsistent with a world in which beef demand is still growing, but in fact it’s not. In crowded developed countries, animals spend much of their lives in intensive feedlots, where they’re given a grain-based ration to get them to slaughter weight in 18 months or less. This is much more productive than having grass-fed cattle living semi-wild on rangelands. In Brazil, animals can live for three years or more before a trip to the abattoir. As major producing regions such as Brazil, the U.S. and China intensify their beef production processes and focus on the breeds that grow fastest, we are eking more beef out of a smaller herd. This intensification means pasturelands already cover less area than at any time since the 1970s. In terms of animal welfare, this isn’t great news — but from the perspective of the climate, it’s almost certainly an improvement. There’s one major reason to doubt this optimistic story: Counting the number of bovids spread across vast rangelands is an imprecise business, so it’s possible the USDA’s numbers are wrong. The United Nations’ Food and Agriculture Organization has a much higher, and still-growing, estimate for the cattle herd — 1.55 billion head, as opposed to the USDA’s 923 million. That appears to largely relate to differences in areas such as Africa and west and central Asia less connected to global trade routes, where the market-oriented USDA’s data-gathering may be weaker than that of the FAO. Both bodies are in agreement that the cattle herd has more or less stopped growing in most of the world, but the FAO’s numbers for Africa alone are enough to offset all the positive news elsewhere. Swathes of sub-Saharan Africa have a ranching, pastoralist culture, like the Americas and Oceania, quite distinct from the crop-growing cultures of Asia and Europe. It would hardly be surprising if rising incomes there saw locals develop the insatiable appetite for beef we associate with Argentines and Americans. Even there, though, it’s worth considering that not every cow is bred primarily for slaughter. The carbon footprint of dairy products is pretty much in line with that of poultry, pork and eggs, and drastically lower than what we see with beef and lamb. We produce about eight times more milk than beef for half the carbon emissions, so if dairies are taking market share from slaughterhouses then emissions may be falling even faster (on the USDA’s numbers) or at least growing more slowly (per the FAO). That’s welcome news. In agriculture as in industry, there’s evidence of progress all around us.

KyKy Tandy scored a season-high 21 points that included a key 3-pointer in a late second-half surge as Florida Atlantic roared back to beat Oklahoma State 86-78 on Thursday in the opening round of the Charleston Classic in Charleston, S.C. Florida Atlantic (4-2) advances to play Drake in the semifinal round on Friday while the Cowboys square off against Miami in the consolation semifinal contest, also Friday. Oklahoma State led by as many as 10 points in the first half before securing a five-point advantage at halftime. The Owls surged back and moved in front with four and a half minutes to play. It was part of an 11-1 run, capped by a 3-pointer from Tandy that made it 75-68 with 2:41 remaining. Ken Evans added 14 points for Florida Atlantic, with Leland Walker hitting for 13 and Tre Carroll scoring 11. The Owls went 35-of-49 from the free throw line as the teams combined for 56 fouls in the game, 33 by Oklahoma State. Khalil Brantley led Oklahoma State (3-1) with 16 points while Robert Jennings added 14 points and 11 rebounds for the Cowboys, who hit one field goal over a 10-minute stretch of the second half while having three players foul out. The Owls were up by as many as seven points in the early minutes and by 13-10 after a layup by Carroll at the 11:32 mark of the first half. Oklahoma State leapfrogged to the front on Abou Ousmane's layup off a Brantley steal, fell behind again on a 3-pointer by Evans and then responded on a 3-pointer by Jennings to take a 17-16 lead. From there, the Cowboys stoked their advantage to double digits when Jamyron Keller canned a shot from beyond the arc with five minutes to play in the half. Florida Atlantic got a layup and a monster dunk from Matas Vokietaitis and a pair of free throws from Walker in a 6-2 run to end the half to pull within 39-34 at the break. Jennings and Ousmane tallied seven points apiece for Oklahoma State over the first 20 minutes, as the Cowboys led despite shooting just 33.3 percent from the floor in the half. Carroll and Vokietaitis scored seven points apiece to pace the Owls, who committed 11 turnovers that translated to seven points for Oklahoma State before halftime. --Field Level MediaSignificant milestones in life and career of Jimmy CarterPresident-elect Donald Trump has filled the key posts for his second term in office, prioritizing loyalty to him after he felt bruised and hampered by internal squabbling during his first term. Some of his choices could face difficult confirmation fights in the Senate, even with Republicans in control, and one candidate has already withdrawn from consideration. Former Florida Rep. Matt Gaetz was Trump's initial pick for attorney general, but he ultimately withdrew following scrutiny over a federal sex trafficking investigation he was embroiled in. Here's a look at Trump's choices: Trump would turn a former critic into an ally as the nation's top diplomat. Rubio , 53, is a noted hawk on China, Cuba and Iran, and was a finalist to be Trump's running mate before the slot went to JD Vance. Rubio is vice chairman of the Senate Intelligence Committee and a member of the Senate Foreign Relations Committee. His selection punctuates the hard pivot Rubio has made with Trump, whom the senator once called a “con man" during his own unsuccessful campaign for the 2016 Republican presidential nomination. Their relationship improved dramatically while Trump was in the White House. Hegseth , 44, was a co-host of Fox News Channel’s “Fox and Friends Weekend” and had been a contributor with the network since 2014. He developed a friendship with Trump, who made regular appearances on the show. Hegseth served in the Army National Guard from 2002 to 2021, deploying to Iraq in 2005 and Afghanistan in 2011 and earning two Bronze Stars. He lacks senior military and national security experience and would oversee global crises ranging from Europe to the Middle East. A woman told police that she was sexually assaulted in 2017 by Hegseth after he took her phone, blocked the door to a California hotel room and refused to let her leave, according to a detailed investigative report recently made public. Hegseth told police at the time that the encounter had been consensual and has denied any wrongdoing. Bessent , 62, is a former money manager for George Soros , a big Democratic donor, and an advocate for deficit reduction . He founded the hedge fund Key Square Capital Management after having worked on and off for Soros Fund Management since 1991. If confirmed by the Senate, Bessent would be the nation’s first openly gay treasury secretary. He told Bloomberg in August that he decided to join Trump’s campaign in part to attack the mounting U.S. national debt. That would include slashing government programs and other spending. Gabbard, 43, is a former Democratic House member from Hawaii who has been accused of echoing Russian propaganda. She unsuccessfully sought the party’s 2020 presidential nomination and left the party in 2022. Gabbard endorsed Trump in August and campaigned often with him. Gabbard has served in the Army National Guard for more than two decades and deployed to Iraq and Kuwait. If confirmed she would come to the role as an outsider compared to her predecessor. The current director, Avril Haines, spent several years in top national security and intelligence positions. Bondi , 59, was Florida's first female attorney general, serving between 2011 and 2019. She was on Trump’s legal team during his first impeachment trial in 2020. Considered a loyalist , Bondi also has served with the America First Policy Institute, a Trump-allied group that has helped lay the groundwork for his future administration. Bondi was among a group of Republicans who showed up to support Trump at his hush-money criminal trial in New York that ended in May with a conviction on 34 felony counts. A fierce defender of Trump, she also frequently appeared on Fox News and has been critical of the criminal cases against him. The Republican U.S. House member narrowly lost her reelection bid on Nov. 5 but had received strong backing from union members in her district. As a potential labor secretary, Chavez-DeRemer would oversee the department's workforce and budget and put forth priorities that affect workers’ wages, health and safety, ability to unionize, and employer’s rights to fire employers, among other responsibilities. Chavez-DeRemer is one of a few House Republicans to endorse the “Protecting the Right to Organize” or PRO Act that would allow more workers to conduct organizing campaigns and penalize companies that violate workers’ rights. The act would also weaken “right-to-work” laws in more than half the states. Lutnick heads the brokerage and investment bank Cantor Fitzgerald and is a cryptocurrency enthusiast. He is co-chair of Trump's transition operation, charged along with Linda McMahon, a former wrestling executive who previously led Trump’s Small Business Administration, with helping the president-elect fill key jobs in his second administration. As secretary, Lutnick would play a key role in carrying out Trump's plans to raise and enforce tariffs. He would oversee a sprawling Cabinet department whose oversight ranges from funding new computer chip factories and imposing trade restrictions to releasing economic data and monitoring the weather. Noem is a well-known conservative who used her two terms as South Dakota's governor to vault to a prominent position in Republican politics. During the COVID-19 pandemic, Noem did not order restrictions like other states, instead declaring South Dakota “open for business.” More recently, Noem faced sharp criticism for writing in her memoir about shooting and killing her dog. She is set to lead a department crucial to the president-elect’s hardline immigration agenda as well as other missions. Homeland Security oversees natural disaster response, the U.S. Secret Service and Transportation Security Administration agents who work at airports. Ratcliffe , a former U.S. House member from Texas, was director of national intelligence during the final year and a half of Trump’s first term. He led U.S. government’s spy agencies during the coronavirus pandemic. If confirmed, Ratcliffe will have held the highest intelligence positions in the U.S. Kennedy , 70, ran for president as a Democrat, then as an independent before he dropped out and then endorsed Trump . He's the son of Democratic icon Robert F. Kennedy, who was assassinated in 1968 during his own presidential campaign. Kennedy's nomination alarmed people who are concerned about his record of spreading unfounded fears about vaccines . For example, he has long advanced the debunked idea that vaccines cause autism. Rollins , 52, is president and CEO of the America First Policy Institute, a group helping to lay the groundwork for Trump's second administration. She is a Texas attorney who was Trump's domestic policy adviser and director of his office of American innovation during his first term. Rollins previously was an aide to former Texas Gov. Rick Perry , who also served in Trump's first term. Rollins also ran the Texas Public Policy Foundation. Duffy is a former House member from Wisconsin who was one of Trump's most visible defenders on cable news. Duffy served in the House for nearly nine years , sitting on the Financial Services Committee and chairing the subcommittee on insurance and housing. He left Congress in 2019 for a TV career and has been the host of “The Bottom Line” on Fox Business. Before entering politics, Duffy was a reality TV star on MTV, where he met his wife, “Fox and Friends Weekend” co-host Rachel Campos-Duffy. They have nine children. Collins is a former Republican congressman from Georgia who gained recognition for defending Trump during his first impeachment trial. Trump was impeached for urging Ukraine to investigate Joe Biden in 2019 during the Democratic presidential campaign, but was acquitted by the Senate. Collins also served in the armed forces himself. He is a chaplain in the United States Air Force Reserve Command. The North Dakota governor , 68, is a former Republican presidential primary contender who endorsed Trump after he dropped out of the running. Burgum then became a serious contender to be Trump’s vice presidential choice in part because of his executive experience and business savvy. He also has close ties to deep-pocketed energy industry CEOs. Trump said Burgum would chair a new National Energy Council and have a seat on the National Security Council, which would be a first for the Interior secretary. A campaign donor and CEO of Denver-based Liberty Energy, Wright is a vocal advocate of oil and gas development, including fracking — a key pillar of Trump’s quest to achieve U.S. “energy dominance” in the global market. He also has been one of the industry’s loudest voices against efforts to fight climate change. Wright said the climate movement around the world is “collapsing under its own weight.” The Energy Department is responsible for advancing energy, environmental and nuclear security of the United States. McMahon, a billionaire professional wrestling mogul , would make a return appearance in a second Trump administration. She led the Small Business Administration from 2017 to 2019 in Trump’s first term and twice ran unsuccessfully in Connecticut as a Republican candidate for the U.S. Senate. She served on the Connecticut Board of Education for a year starting in 2009 and has spent years on the board of trustees for Sacred Heart University. She has expressed support for charter schools and school choice. Zeldin does not appear to have any experience in environmental issues, but is a longtime supporter of the former president. The 44-year-old former U.S. House member from New York wrote on X , “We will restore US energy dominance, revitalize our auto industry to bring back American jobs, and make the US the global leader of AI" and "we will do so while protecting access to clean air and water.” Trump often attacked the Biden administration’s promotion of electric vehicles, and incorrectly referred to a tax credit for EV purchases as a government mandate. Trump also often said his administration would “drill, baby, drill,” referring to his support for expanded petroleum exploration. Turner is a former NFL player and White House aide. He ran the White House Opportunity and Revitalization Council during Trump’s first term in office. Trump, in a statement, credited Turner, the highest-ranking Black person he’s yet selected for his administration, with “helping to lead an Unprecedented Effort that Transformed our Country’s most distressed communities.” Greer is a partner at King & Spalding, a Washington law firm. If confirmed by the Senate, he would be responsible for negotiating directly with foreign governments on trade deals and disputes, as well as memberships in international trade bodies such as the World Trade Organization. He previously was chief of staff to Robert Lighthizer, who was the trade representative in Trump's first term. Wiles , 67, was a senior adviser to Trump’s 2024 presidential campaign and its de facto manager. She has a background in Florida politics , helping Ron DeSantis win his first race for Florida governor. Six years later, she was key to Trump’s defeat of him in the 2024 Republican primary. Wiles’ hire was Trump’s first major decision as president-elect and one that could be a defining test of his incoming administration considering her close relationship with him. Wiles is said to have earned Trump’s trust in part by guiding what was the most disciplined of Trump’s three presidential campaigns. Waltz is a three-term Republican congressman from east-central Florida. A former Army Green Beret , he served multiple tours in Afghanistan and worked in the Pentagon as a policy adviser when Donald Rumsfeld and Robert Gates were defense chiefs. He is considered hawkish on China, and called for a U.S. boycott of the 2022 Winter Olympics in Beijing due to its involvement in the origin of COVID-19 and its mistreatment of the minority Muslim Uighur population. Hassett, 62, is a major advocate of tax cuts who was chairman of the Council of Economic Advisers in the first Trump term. In the new role as chairman of the National Economic Council, Trump said Hassett will play an important role in helping American families recover from inflation as well as in renewing and improving tax cuts Trump enacted in 2017, many of which are set to expire after 2025. Homan, 62, has been tasked with Trump’s top priority of carrying out the largest deportation operation in the nation’s history. He led the U.S. Immigration and Customs Enforcement in Trump's first administration. Democrats have criticized Homan for defending Trump’s “zero tolerance” policy on border crossings in the first term, which led to the separation of thousands of parents and children seeking asylum at the border. Vought, 48, held the position during Trump’s first presidency. He the founded the Center for Renewing America, a think tank that describes its mission as “renew a consensus of America as a nation under God.” Vought also was closely involved with Project 2025 , a conservative blueprint for Trump’s second term that Trump tried to distance himself from during the campaign. Miller, an immigration hardliner , was a vocal spokesperson during the presidential campaign for Trump’s priority of mass deportations. The 39-year-old was a senior adviser during Trump’s first term. Miller has been a central figure in some of Trump’s policy decisions, notably his move to separate thousands of immigrant families. Trump argued throughout the campaign that the nation’s economic, national security and social priorities could be met by deporting people living illegally in the U.S. Scavino was an adviser in all three of the president-elect's campaigns and was described by the transition team as one of “Trump’s longest serving and most trusted aides." He will be deputy chief of staff and assistant to the president. Scavino previously ran Trump’s social media profile in the White House. Blair was political director for Trump’s 2024 campaign and for the Republican National Committee. He will be deputy chief of staff for legislative, political and public affairs and an assistant to the president. Blair was key to Trump’s economic messaging during his winning White House comeback campaign. Budowich is a veteran Trump campaign aide who launched and directed Make America Great Again, Inc., a super PAC that supported Trump’s 2024 campaign. He will be deputy chief of staff for communications and personnel and assistant to the president. Leavitt , 27, was Trump's campaign press secretary and currently a spokesperson for his transition. She would be the youngest White House press secretary in history. Leavitt worked in the White House press office during Trump's first term. In 2022, she ran for Congress in New Hampshire, winning a 10-way Republican primary before losing to Democratic Rep. Chris Pappas. McGinley was Cabinet secretary during Trump's first administration and was outside legal counsel for the Republican National Committee's election integrity effort during the 2024 campaign. The 67-year-old Witkoff is the president-elect's golf partner and they were golfing at Trump's club in West Palm Beach, Florida, on Sept. 15, when the former president was the target of a second attempted assassination. Trump also named Witkoff co-chair, with former Georgia Sen. Kelly Loeffler, of his inaugural committee. Kellogg , 80, is a highly decorated retired three-star general and one of the architects of a staunchly conservative policy book that lays out an “America First” national security agenda for Trump's second term. He has long been Trump’s top adviser on defense issues and served as national security adviser to Vice President Mike Pence . Kellogg also was chief of staff of the National Security Council under Trump and stepped in as an acting national security adviser for Trump after Michael Flynn resigned the post. Huckabee is a staunch defender of Israel and his intended nomination comes as Trump has promised to align U.S. foreign policy more closely with Israel's interests. Huckabee, who ran unsuccessfully for the Republican presidential nomination in 2008 and 2016, has been a popular figure among evangelical Christian conservatives, many of whom support Israel due to Old Testament writings that Jews are God’s chosen people and that Israel is their rightful homeland. Huckabee has rejected a Palestinian homeland in territory occupied by Israel. His daughter, Sarah Huckabee Sanders, served as White House press secretary in Trump's first term. Stefanik, 40, is a U.S. representative from New York and one of Trump's staunchest defenders dating to his first impeachment trial. She was elected chair of the House Republican Conference in 2021, the third-highest position in House leadership, after then-Rep. Liz Cheney was removed from the post after she publicly criticized Trump for falsely claiming he won the 2020 election. Stefanik’s questioning of university presidents over antisemitism on their campuses helped lead to two of those presidents resigning, further raising her national profile. A former acting attorney general during Trump's first administration and tight end on the University of Iowa football team, Whitaker , 55, has a background in law enforcement but not in foreign policy. A fierce Trump localist, Whitaker, is also a former U.S. attorney in Iowa and served as acting attorney general between November 2018 and February 2019 without Senate confirmation, until William Barr was confirmed for the role. That was when special counsel Robert Mueller’s investigation into Russian election interference was drawing to a close. Whitaker also faced questions about his past business dealings, including his ties to an invention-promotion company that was accused of misleading consumers. A Republican congressman from Michigan who served from 1993 to 2011, Hoekstra was ambassador to the Netherlands during Trump's first term. Oz , 64, is a former heart surgeon who hosted “The Dr. Oz Show,” a long-running daytime TV talk show. He ran unsuccessfully for the U.S. Senate as the Republican nominee in 2022 and is an outspoken supporter of Trump, who endorsed Oz’s bid for elected office. Makary is a Johns Hopkins surgeon and author who argued against pandemic lockdowns. He routinely appeared on Fox News during the COVID-19 pandemic and wrote opinion articles questioning masks for children. He cast doubt on vaccine mandates but supported vaccines generally. Makary also cast doubt on whether booster shots worked, which was against federal recommendations on the vaccine. Nesheiwat is a general practitioner who serves as medical director for CityMD, a network of urgent care centers in New York and New Jersey. She has been a contributor on Fox News. Weldon is a former Florida congressman who recently ran for a Florida state legislative seat and lost; Trump backed Weldon’s opponent. In Congress, Weldon weighed in on one of the nation’s most heated debates of the 1990s over quality of life and a right-to-die and whether Terri Schiavo, who was in a persistent vegetative after cardiac arrest, state should have been allowed to have her feeding tube removed. He sided with the parents who did not want it removed. Bhattacharya , 56, is a critic of pandemic lockdowns and vaccine mandates. As head of the NIH, the leading medical research agency in the United States, Trump said Bhattacharya would work with Kennedy Jr. to direct U.S. medical research and make important discoveries that will improve health and save lives. Bhattacharya is professor at Stanford University School of Medicine and was one of three authors of the Great Barrington Declaration, an October 2020 open letter maintaining that lockdowns during the COVID-19 pandemic were causing irreparable harm. Gaetz, 42, withdrew from consideration to become the top law enforcement officer of the United States amid fallout over a federal sex trafficking investigation that cast doubt on his ability to be confirmed by the Senate. In choosing Gaetz, Trump had passed over more established lawyers whose names had been floated as possible contenders for the job. Gaetz resigned from Congress after Trump announced him on Nov. 13. The House Ethics Committee has been investigating an allegation that he paid for sex with a 17-year-old. Gaetz has denied wrongdoing. Associated Press writers Colleen Long, Zeke Miller, Farnoush Amiri, Lolita C. Baldor, Jill Colvin, Matthew Daly, Edith M. Lederer, Adriana Gomez Licon, Lisa Mascaro, Chris Megerian, Michelle L. Price, Will Weissert and Darlene Superville contributed to this report.

Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Stock market today: Rising tech stocks pull Wall Street to another record

Letter to the Editor: What will Martin County do?

Stock market today: Rising tech stocks pull Wall Street to another record

NoneHeidi Jorgensen, owner of Jem Custom Designs in Forsyth, combines technology with artistry to create beautiful, laser-engraved wood décor. Since 2020, her business has grown from a small creative endeavor to a full-time passion, specializing in intricate designs that range from personalized earrings and door signs to elaborate travel maps and wall hangings. A Pandemic Pivot to Crafting Jorgensen offers complex, multi-piece designs made from 100 different cuts of wood. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. This custom-made travel map comes with a box of individually cut states to be added to map. Jem Custom Designs items range from cutting boards to games and intricate art pieces. Get our free email newsletters — latest headlines and e-edition notifications.